Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis

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Novel suppressive function of transitional 2 B cells in experimental arthritis.

The immune system contains natural regulatory cells important in the maintenance of tolerance. Although this suppressive function is usually attributed to CD4 regulatory T cells, recent reports have revealed an immunoregulatory role for IL-10-producing B cells in the context of several autoimmune diseases including collagen-induced arthritis. In the present study, we attribute this suppressive ...

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Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis

OBJECTIVE Premature senescence of lymphocytes is a hallmark of inflammatory rheumatic diseases such as rheumatoid arthritis (RA). Early T-cell aging affects conventional T-cells but is presumably not limited to this cell population; rather it might also occur in the regulatory T-cells (Tregs) compartment. In RA, Tregs fail to halt aberrant immune reactions and disease progression. Whether this ...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2007

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.178.12.7868